About the beginning of the year 1797 a youth of nineteen donned the uniform of a surgeon first mate, and entered upon his duties as a member of the company of H.M.S. Standard, stationed at the Nore. This was William Redfern, destined in after life to play a very conspicuous part in the early history of the colony of New South Wales.
Mutiny of the Nore
In May of the year mentioned certain members of the Standard's crew complained of the food supplied to them, and asked the young surgeon’s mate to support their protest. He agreed to do so, and advised the men to 'make a united appeal'. Unfortunately for him and for them instead of petitioning in the proper way, the crews mutinied. 
This was In May 1797, and the event is known in history as the 'Mutiny of the Nore.' The result of it is well known. The leaders were overpowered and hanged; and the others punished with varying degrees of severity.
The Trial of the mutineers of the Standard man of war concluded at Greenhith on Friday last, when John Burrows, Joseph Hudson, William Redfern, surgeon's mate, and Thomas Lunness, alias Linnes, received sentence of death; but the Court recommended to his Majesty's mercy Joseph Hudson on account of a wound he received in his Majesty's service, which deprived him of his senses after having drunk strong liquor; and William Redfern was likewise recommended to mercy, on account of his professional situation leading him more amongst the mutineers than any of the other officers. The Court found the charge proved only in part against Bryan Finn, alias Fenn, and Joseph Glaves, and sentenced to former to receive three hundred lashes, and the latter two hundred and fifty. The trial of the following persons belonging to the same ship ended on Monday sennight; William Holdsworth, Henry Freeman, John, alias Jonathan Davis, Bartholomew Connery, William Jones, Sampson Harris, and Thomas Sael, seamen. They all received sentence of death except Sampson Harris, respecting whom the Court found the charge proved only in part, and sentenced him to receive two hundred lashes. No more of the mutineers are to be tried at Greenhithe. On the conclusion of the trial of the people of the Standard, Vice Admiral Patley struck his flag on board the Centaur, which ship, with the Neptune and some others, is under orders to join the Channel fleet.
William Redfern was kept in prison for four years awaiting transportation. 
His name is recorded in the UK Prison Hulk Registers - William Redfern, age 32 - Tried on the Neptune 22 August 1797, sentenced to NSW for Life. Received on to the Perseus hulk at Portsmouth on 1 April 1801. Sent on board the Canada convict ship 6 June 1801. 
The three convicts ships Nile, Canada and Minorca sailed together for New South Wales, so at some point William Redfern apparently transferred to the Minorca. During the voyage he assisted the surgeon. The Minorca arrived in Sydney on 14 December 1801.
Thomas McCann and George Lewis were also tried for mutiny in 1797 and arrived in New South Wales on the Minorca.
On his arrival in Sydney William Redfern was sent to Norfolk Island where he was employed as the civil surgeon.
In 1802 he was appointed by Lieut-Col Foveaux, who was then in charge of Norfolk Island to the post of assistant surgeon. In this same year he was granted by Governor King, an absolute pardon.
In 1808 he was appointed Assistant Surgeon at the Dawes Point Convict Hospital in Sydney.
William Redfern was the first person to receive an Australian medical qualification, and was the first teacher of Australian medical students. He instigated important reforms in the management of convict ship voyages following the arrival of the Surry and General Hewitt in 1814. He was heavily involved in many aspects of colonial life in business and in his professional capacity - In addition to his work in the hospital wards, Redfern conducted a daily out-patient clinic for men from the convict gangs. He also had the most extensive private practice in the colony, for he was the most popular doctor in the settlement and his services were widely sought. He was the family doctor to the Macarthurs and the Macquaries and attended the birth of Governor Macquarie's son. His professional skill was highly regarded by his colleagues and he had the reputation of being the best obstetrician in the colony . He assisted Blaxcell, Riley and Wentworth in the building of the new General Hospital 1811 - 1816. In 1815 he accompanied Governor Macquarie on a trip across the Blue Mountains; in 1817 he was one of the first directors of the Bank of New South Wales. He supplied wool to the Parramattta Factory in 1821 and imported sugar from Mauritius in 1827.
After almost eighteen years in public service as assistant-surgeon, William Redfern expected to succeed D'Arcy Wentworth to the position principal surgeon in 1818 , however despite recommendations from Governor Macquarie, James Bowman, was appointed to the position. Almost immediately Redfern resigned.
In correspondence dated 14 July 1820 from Governor Macquarie to Earl Bathurst, Macquarie requested that Redfern receive a pension or half pay equal to five shillings. He left no doubt as to his admiration for the surgeon:
The Medical Services of Assistant Surgeon Redfern in this
Colony for nearly Eighteen Years past have been Most Arduous,
Assiduous and eminently Useful. He is a Man of Very Superior
Medical Talents and professional Skill. I therefore Consider
his Retirement as a great Public Loss, and I am Convinced it
will be generally felt by this Community. It is to Mr. Redfern's
able Report and most Judicious Suggestions, which I had the
Honor of transmitting to Your Lordship and to the Commissioners of the Transport Board in the Month of October, 1814,
on the Subject of the great Mortality and bad Medical Treatment
of Convicts on their passage from Europe to this Country, that
the present improved System of sending Naval Surgeons as Superintendent Surgeons in Charge of the Convicts is owing.
Your Lordship and the Commissioners of the Transport Board
having ordered it to be immediately Acted upon.
 This was after the arrival of the General Hewitt in 1814 when 34 prisoners died on the voyage out.
William Redfern married Miss Sarah Wills, the daughter of Edward Spenser Wills of Geelong and Sydney in March 1811. Eliza Wills, the eldest daughter of Edward Spenser Wills married Major Antill, a close friend of William Redfern.
William and Sarah Redfern had two sons.- William Machlan Macquarie Redfern b. 1819 and Joseph Foveaux Redfern died in 1830 aged 7.
William Redfern was granted 70 acres of land. Another 30 acres given to Sarah Wills by her mother as a wedding gift adjoined his grant. This 100 acres became the suburb of Redfern.
William Redfern came to own much land - at Bathurst, Cowra and Geelong and also where his built his home on the George's River named Campbell Fields.
Campbellfield aka Redfern's Cottage at Minto. -Campbelltown Historical Society
William Redfern visited England in 1821 and 1825. In 1828 he took his son William to Edinburgh to be educated. Although he intended to return, he died there in July 1833 at the age of 58.
He was buried in the New Calton Burying Ground.
Overlooking the burial ground is a tower designed to prevent thieves from snatching the recently deceased. Find out more about the tower at Atlas Obscura
William Redfern, the First Australian
By NORMAN J. DUNLOP, B.A., B.Sc., M.B., Ch.M. (Fellow).
Through the researches of A. A. Scot Skirving, Esq.,
F.R.C.S., of Edinburgh, Scotland, and the courtesy of his
brother, Dr. Robert Scot Skirving, of this city, it is now
possible to state where all that is mortal of William Redfern rests. The records in the Edinburgh Registrar-General’s Office have been searched, and a notice has
been found in the records of the Calton Burying Ground
that tells us that William Redfern, aged fifty-eight years,
formerly a surgeon living at 18 Lothian Street, Edinburgh, was buried in the New Ground in a grave purchased for his executors by Mr. David Walker. The
cause of death is not stated. This entry is dated July
23, 1833. The “New” Calton Cemetery is called so in
distinction to the “Old” Calton Burying Ground, which
had reached saturation point before Redfern died. Both
cemeteries are south of Calton Hill. It is of interest to
note that the Old Calton Cemetery contains the memorial
to W illiam Skirving and his companions. Although the
cemetery in which he was interred can be named with
certainty, the exact spot where Redfern was buried is
unknown. Had there been a headstone containing a
legend, Dr. Archie Scot Skirving would have had it
photographed. Royal Historical Journal and proceedings, Vol. 14 Part. 5 (1928) - Trove
3). Sarah Redfern (William's widow) married James Alexander Esq., at Glasgow on 24 June 1834
 Home Office: Convict Prison Hulks: Registers and Letter Books; Class: HO9; Piece: 8 Description Year Range: 1801-1836 Source Information Ancestry.com. UK, Prison Hulk Registers and Letter Books, 1802-1849
 The Life and Work of William Redfern - The Annual Post-Graduate Oration, delivered on April 29, 1953, in the Great Hall of the University of Sydney. By Edward Ford, Dean of the Faculty of Medicine and Professor of Preventive Medicine in the University of Sydney.